"Open my eyes, that I may see Wondrous things from Your law" (Psalm 119:18, NKJV).
"So now, brethren, I commend you to God and to the word of His grace, which is able to build you up and give you an inheritance among all those who are sanctified" (Acts 20:32, NKJV).
"'For it is not a futile thing for you, because it is your life..." (Deut. 32:47, NKJV).
"Your words were found, and I ate them, And Your word was to me the joy and rejoicing of my heart..." (Jeremiah 15:16, NKJV).
Readers of the Bible that fail to glean anything substantial, inspiring, or convicting have missed the point of not knowing the Author first; the Bible is meant to be a closed book to anyone nonspiritual, for it is spiritually discerned (cf. 1 Cor. 2:14). There are foundational principles for decoding the Word just like for any book, only more so. If one is unaware of the main message of salvation and the main diagnosis of sin and the main enemy of Satan, one will not comprehend anything intelligible or meaningful and inspiring. We don't just read it to get inspired like one would read Shakespeare, but to be transformed and changed--it wasn't written to increase our knowledge (so don't read it for merely academic pursuits!), but to change our lives, for the Word is powerful, and living, and has the Spirit giving it convicting influence. Sometimes readers get out of focus and experience "Bible fatigue" whereby it's lost some pizzazz or original flavor due to overly familiarization with the text; a new translation or version may be in order to refresh yourself and get back on track in the Word.
Many people claim to read the Word but have only given it passing attention and perusal. What they ought to try is to let the Bible read them and go through them as they go through it and read it (to use figures of speech). The Bible has a way of feeding you and making you hungry for more--it quenches your thirst and makes you thirsty--nothing else will satisfy once experienced! Our goal is not so much to know the Word as the Author (it's a means to an end), and in our efforts to be people of the Book, to obey it and know God through it, as Jesus said in John 17:17, NKJV, "Sanctify them by Your truth. Your Word is truth." Our goal in learning the Word is not to just become familiar with it, but with the Author, and subsequently in a living relationship in which He speaks to us through it.
Many Christians have difficulty understanding the Word for lack of reading skill and of basic hermeneutics. One must always put them into context (social, historical, paragraph, book, and the whole analogy of Scripture itself). Another key is to see it all as a revelation of Christ and who He is, as revealed developmentally and gradually throughout the Bible; each book shows Christ in a new light and we can know Him in this way. The Bible is written in many genres: historical narrative; poetry; didactive or teaching letters; prophecy; sermons; wisdom or proverbs; songs and psalms; and parables or figures of speech, beating around the bush or plainspoken. One reason students don't read adequately is the biblical terminology or vocabulary and they don't avail themselves of dictionaries and Bible study aids. A simple solution may be another version or study Bible! The primary reason not to get anything out of the Word is not reading with a purpose or not depending on the Spirit's illumination and guidance. If we don't put anything into it or any effort, we can expect little reward (as Psalm 119:162, NKJV, says, "I rejoice at Your word As one who finds great treasure").
Furthermore, ask questions when studying about: lessons to learn; principles to know; promises to claim; errors to avoid; duties to perform; commands to obey; prayers to echo; warnings to heed; truth to realize; and examples to follow. We so often neglect the main message and don't see the forest for the trees; keep the main thing the main thing! Whether you understand it or get anything out of it is not God's fault, but a mirror on the condition of your soul and openness to His will and Spirit. A guideline to follow is to bring an open mind, needy and thirsty heart, and obedient spirit to the Word! In other words, expect God to speak to your heart. Once you've had an "Aha!" moment in the Owner's Manual of life or an existential encounter with the Word, you'll be hooked and always eager to find the Bread of Life in the Word, which is the only message that can satisfy.
To be purpose-oriented, one must simply seek the purpose of the text as the author intended (what occasioned it?), before applying it to yourself--that entails reading with a purpose and not aimlessly. Interpretation comes before application. A mistake by the beginner is to read into the Word, rather than what's in it or reading out of it. Finally, you can't just read any verse at random and expect it to be a divine message from the Almighty! The whole idea of reading with a purpose is to arrive at some take-away to meditate on as spiritual food for the day. The idea is to unlock the Word one verse at a time, but not to lose focus on the main message of salvation in Christ. This is called bibliomancy and is not recommended. (To get a clear view, one must see the big picture and know the gradual unfolding of the redemption story, or be able to walk through it.) Soli Deo Gloria!